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The estrogen receptor in the growth plate: implications for pubertal growth.
[aromatase deficiency]
It
is
well
established
that
estrogen
is
essential
for
statural
growth
during
puberty
,
but
until
recently
it
was
generally
accepted
that
the
role
of
estrogen
was
negligible
during
puberty
in
boys
.
Clinical
findings
in
three
male
patients
,
one
with
an
inactivating
mutation
in
the
estrogen
receptor
and
two
with
P-
450
aromatase
deficiency
,
have
,
however
,
advanced
our
knowledge
of
the
role
of
estrogen
in
the
male
.
It
has
become
apparent
that
estrogen
(
1
)
initiates
the
pubertal
growth
spurt
,
(
2
)
causes
growth
plate
fusion
at
the
end
of
puberty
,
and
(
3
)
augments
accrual
of
bone
during
puberty
.
Two
estrogen
receptors
(
alpha
and
beta
)
mediate
the
actions
of
estrogen
,
and
the
presence
of
both
has
been
demonstrated
in
the
growth
plate
.
The
mechanism
by
which
estrogen
acts
locally
on
the
growth
plate
,
however
,
remains
largely
unknown
.
With
the
recent
development
of
knockout
models
for
both
estrogen
receptors
,
attempts
are
being
made
to
unravel
the
local
actions
of
estrogen
in
order
to
characterize
further
their
roles
in
the
regulation
of
longitudinal
growth
.
Diseases
Validation
Diseases presenting
"two with p-450 aromatase deficiency"
symptom
aromatase deficiency
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