Effect of estrogen replacement on insulin sensitivity, serum lipid and bone resorption marker in hypogonadal males.

[aromatase deficiency]

Recent reports of osteoporosis in congenital estrogen deficiency in humans from estrogen resistance or aromatase deficiency have called attention to the importance of estrogen in males . It is the purpose of the present study to evaluate the effects of low - dose estrogen on glucose , lipid and bone metabolism in males with hypogonadism . Nine Thai males with primary or secondary hypogonadism were included in the study . Testosterone was discontinued at least 8 weeks before the study . The subjects received 0 .3 mg of conjugated equine estrogen (CEE ) daily for 4 weeks . Serum C-terminal telopeptide of type 1 collagen (CTX ), total cholesterol (TC ), LDL cholesterol (LDL-C ), HDL cholesterol (HDL-C ), triglyceride (TG ) and parameters related to insulin sensitivity were measured at baseline and 4 weeks after treatment . Insulin sensitivity was assessed by frequent intravenous glucose tolerance test . The mean age of subjects was 35 .77 years (22 -70 years ). Insulin sensitivity index (SI ) did not change significantly after the administration of CEE (P =0 .09 ). Likewise , no change in acute insulin response (AIR (glucose )) was detected . However , glucose effectiveness (SG ) significantly decreased after CEE (P <0 .05 ). No significant change in serum TC , LDL-C , HDL-C or TG was detected . In regard to bone turnover , serum CTX significantly decreased after CEE administration (P <0 .05 ). We concluded that low -dose estrogen administration in hypogonadal males for 4 weeks causes a decrease in bone turnover and an increase in glucose effectiveness . No effect on serum lipid concentrations or insulin sensitivity and secretion was detected .

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aromatase deficiency

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