Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Effect of estrogen replacement on insulin sensitivity, serum lipid and bone resorption marker in hypogonadal males.
[aromatase deficiency]
Recent
reports
of
osteoporosis
in
congenital
estrogen
deficiency
in
humans
from
estrogen
resistance
or
aromatase
deficiency
have
called
attention
to
the
importance
of
estrogen
in
males
.
It
is
the
purpose
of
the
present
study
to
evaluate
the
effects
of
low
-
dose
estrogen
on
glucose
,
lipid
and
bone
metabolism
in
males
with
hypogonadism
.
Nine
Thai
males
with
primary
or
secondary
hypogonadism
were
included
in
the
study
.
Testosterone
was
discontinued
at
least
8
weeks
before
the
study
.
The
subjects
received
0
.
3
mg
of
conjugated
equine
estrogen
(
CEE
)
daily
for
4
weeks
.
Serum
C-
terminal
telopeptide
of
type
1
collagen
(
CTX
)
,
total
cholesterol
(
TC
)
,
LDL
cholesterol
(
LDL-C
)
,
HDL
cholesterol
(
HDL-C
)
,
triglyceride
(
TG
)
and
parameters
related
to
insulin
sensitivity
were
measured
at
baseline
and
4
weeks
after
treatment
.
Insulin
sensitivity
was
assessed
by
frequent
intravenous
glucose
tolerance
test
.
The
mean
age
of
subjects
was
35
.
77
years
(
22
-
70
years
)
.
Insulin
sensitivity
index
(
SI
)
did
not
change
significantly
after
the
administration
of
CEE
(
P
=
0
.
09
)
.
Likewise
,
no
change
in
acute
insulin
response
(
AIR
(
glucose
)
)
was
detected
.
However
,
glucose
effectiveness
(
SG
)
significantly
decreased
after
CEE
(
P
<
0
.
05
)
.
No
significant
change
in
serum
TC
,
LDL-C
,
HDL-C
or
TG
was
detected
.
In
regard
to
bone
turnover
,
serum
CTX
significantly
decreased
after
CEE
administration
(
P
<
0
.
05
)
.
We
concluded
that
low
-dose
estrogen
administration
in
hypogonadal
males
for
4
weeks
causes
a
decrease
in
bone
turnover
and
an
increase
in
glucose
effectiveness
.
No
effect
on
serum
lipid
concentrations
or
insulin
sensitivity
and
secretion
was
detected
.
Diseases
Validation
Diseases presenting
"total cholesterol"
symptom
acute rheumatic fever
adrenal incidentaloma
aromatase deficiency
classical phenylketonuria
cystinuria
oral submucous fibrosis
phenylketonuria
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom