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Neurological effects of aromatase deficiency in the mouse.
[aromatase deficiency]
In
the
brain
,
the
conversion
from
androgen
into
estrogen
is
an
important
process
for
the
differentiation
of
the
brain
function
in
male
rodents
.
The
aromatase
is
expressed
in
some
nucleus
of
the
brain
.
To
assess
the
functional
significance
of
the
aromatase
gene
in
development
and
activation
of
sex-
specific
behavior
,
we
analyzed
behavioral
phenotypes
of
the
aromatase
knockout
(
ArKO
)
male
mice
.
ArKO
males
obviously
decreased
their
fertility
and
showed
deficits
in
male
sexual
behavior
including
mount
,
intromission
and
ejaculation
.
Noncontact
penile
erection
was
not
significantly
affected
by
defect
of
the
aromatase
gene
.
A
reduction
of
aggressive
behavior
against
male
intruders
was
also
observed
in
ArKO
males
,
while
they
tend
to
exhibit
aggression
toward
estrous
females
during
male
copulatory
tests
.
Moreover
,
the
infanticide
toward
the
pups
was
observed
in
the
ArKO
males
,
whereas
characteristic
parental
behavior
,
but
not
infanticide
was
observed
in
wild-
type
males
.
These
results
indicate
that
aromatase
gene
expression
is
a
critical
step
not
only
for
motivational
and
consummatory
aspects
of
male
sexual
behavior
,
but
also
for
aggressive
and
parental
behaviors
in
male
mice
.
Diseases
Validation
Diseases presenting
"but also for aggressive and parental behaviors in male mice"
symptom
aromatase deficiency
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