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A case of xanthinuria: a study on the metabolism of pyrazinamide and allopurinol.
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A
74
-
year
-old
female
was
diagnosed
as
having
xanthinuria
by
measurement
of
the
uric
acid
level
in
plasma
,
purine
bases
in
urine
and
activity
of
xanthine
oxidase
in
the
duodenal
mucosa
.
The
determination
of
the
urinary
excretion
of
purine
bases
in
her
family
demonstrated
a
slightly
increased
urinary
excretion
of
oxypurines
in
her
younger
brother
,
suggesting
that
he
was
a
heterozygote
.
The
pyrazinamide-loading
test
and
allopurinol-loading
test
demonstrated
that
she
could
neither
metabolize
pyrazinoic
acid
into
5
-
hydroxypyrazinoic
acid
nor
allopurinol
into
oxypurinol
,
although
there
was
a
slight
metabolizing
of
prazinamide
into
5
-
hydroxypyrazinamide
.
This
suggested
that
she
belonged
to
the
subgroup
which
can
neither
metabolize
pyrazinamide
into
5
-
hydroxypyrazinamide
,
pyrazinoic
acid
into
5
-
hydroxypyrazinoic
acid
nor
allopurinol
into
oxypurinol
.
