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An immunoreactive xanthine oxidase protein-possessing xanthinuria and her family.
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The
presence
of
immunoreactive
xanthine
oxidase
protein
was
proven
in
a
xanthinuric
patient
,
using
a
polyclonal
antibody
against
xanthine
oxidase
.
The
antibody
was
raised
against
purified
human
liver
xanthine
oxidase
in
a
rabbit
.
Double
immunodiffusion
method
demonstrated
the
existence
of
an
immunologically
reactive
xanthine
oxidase
which
did
not
possess
xanthine
oxidase
activity
.
In
addition
,
urinary
excretion
of
oxypurines
in
the
patient
and
her
family
was
investigated
.
The
results
indicated
that
a
brother
and
a
sister
had
xanthinuria
.
