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Bilateral osteonecrosis of the femoral head in an adult man affected by congenital estrogen deficiency.
[aromatase deficiency]
Osteonecrosis
of
femoral
head
is
related
to
different
predisposing
factors
.
The
pathogenesis
is
not
completely
understood
,
but
an
ischemic
impairment
seems
to
be
one
of
the
major
determinants
of
bone
necrosis
.
The
association
of
bilateral
necrosis
of
femoral
heads
and
congenital
aromatase
deficiency
is
here
reported
.
The
absence
of
estrogen
activity
,
as
well
as
the
persistence
of
unfused
epiphyses
for
a
long
period
of
life
,
may
be
involved
in
the
determinism
of
bilateral
necrosis
of
bone
femoral
heads
.
The
possibility
of
development
of
bone
necrosis
in
patients
affected
by
congenital
estrogen
deficiency
needs
to
be
considered
and
magnetic
resonance
imaging
can
be
a
useful
method
for
an
early
detection
of
this
disease
.
Diseases
Validation
Diseases presenting
"as well as the persistence of unfused epiphyses for a long period of life"
symptom
aromatase deficiency
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