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Comparison of capillary electrophoretic and liquid chromatographic determination of hypoxanthine and xanthine for the diagnosis of xanthinuria.
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A
capillary
electrophoretic
(
CE
)
method
for
the
determination
of
hypoxanthine
and
xanthine
in
urine
was
developed
to
diagnose
xanthinuria
.
The
linearity
was
excellent
up
to
200
mumol
l-
1
for
the
two
compounds
and
the
limit
of
quantitation
was
2
mumol
l-
1
.
A
comparison
o
the
results
obtained
using
CE
was
made
with
those
obtained
by
the
high
-performance
liquid
chromatographic
(
HPLC
)
technique
described
previously
.
With
regard
to
specificity
,
sensitivity
and
reproducibility
,
the
results
are
similar
but
CE
is
more
rapid
than
HPLC
.
