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[Sex differentiation of central nervous system--brain of man and woman].
[aromatase deficiency]
Sex
differentiation
of
human
brain
is
mostly
dependent
on
the
prenatal
exposure
to
androgen
(
testosterone
)
.
Congenital
aromatase
deficiency
does
not
disturb
male
brain
development
in
men
.
This
is
quite
different
from
experimental
evidence
from
rodents
whose
brains
need
intraneuronal
aromatization
from
androgen
to
estrogen
to
induce
sex
differentiation
.
There
is
evidence
for
male-
female
differences
in
brain
structures
.
Some
of
them
(
INHA
-
3
)
appear
to
be
related
with
sexual
orientation
.
The
other
(
BNST
)
might
participate
in
forming
gender-identity
.
In
addition
,
sexually
dimorphic
features
are
recognized
in
some
cognitive
activities
.
The
possible
involvement
of
genetic
factors
in
human
brain
sex
differentiation
is
also
discussed
.
Diseases
Validation
Diseases presenting
"brain structures"
symptom
22q11.2 deletion syndrome
aromatase deficiency
hydrocephalus with stenosis of the aqueduct of sylvius
pyruvate dehydrogenase deficiency
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