Cholesterol feeding prevents adiposity in the obese female aromatase knockout (ArKO) mouse.

[aromatase deficiency]

The aromatase (ArKO ) knockout mouse develops obesity marked by increased gonadal fat depots . This obesity is characterized by pronounced hypertrophy and hyperplasia in adipocytes with corresponding increases in transcripts involved in fat development . Aromatase deficiency in mice and humans with natural mutations of the aromatase gene also leads to metabolic syndrome , particularly hepatic steatosis . In ArKO mice , this hepatic steatosis , the increased body weight and serum triglycerides are surprisingly prevented by cholesterol feeding . We sought to investigate whether the reduction in body weight upon cholesterol feeding is reflected in gonadal fat depots , which account for a large percentage of body weight in the ArKO mouse . Indeed , gonadal fat depots in female ArKO mice were significantly reduced after cholesterol feeding . Concomitantly , adipocyte hyperplasia and hypertrophy were dramatically reduced upon cholesterol feeding in ArKO mice . Real-time PCR analysis revealed concurrent changes with adipocyte volume in the levels of lipoprotein lipase , caveolin-1 and CD 59 transcripts . Little change was observed in levels of transcripts involved in de novo fatty acid synthesis , beta -oxidation , lipolysis , differentiation and cholesterol metabolism , suggesting that cholesterol feeding prevents hyperplasia and hypertrophy of ArKO adipocytes , possibly as a consequence of changes in transcript levels of lipoprotein lipase and therefore fatty acid uptake .

Diseases
Validation

Diseases presenting "obesity" symptom

acute rheumatic fever

adrenal incidentaloma

aniridia

aromatase deficiency

carcinoma of the gallbladder

cohen syndrome

congenital adrenal hyperplasia

cushing syndrome

cystinuria

esophageal adenocarcinoma

esophageal carcinoma

esophageal squamous cell carcinoma

familial hypocalciuric hypercalcemia

familial mediterranean fever

heparin-induced thrombocytopenia

kabuki syndrome

monosomy 21

phenylketonuria

primary hyperoxaluria type 1

sneddon syndrome

werner syndrome

wolf-hirschhorn syndrome

x-linked adrenoleukodystrophy

This symptom has already been validated