Developmental trajectories in syndromes with intellectual disability, with a focus on Wolf-Hirschhorn and its cognitive-behavioral profile.

[wolf-hirschhorn syndrome]

Few studies exist of developmental trajectories in children with intellectual disability , and none for those with subtelomeric deletions . We compared developmental trajectories of children with Wolf-Hirschhorn syndrome to other genetic disorders . We recruited 106 children diagnosed with fragile X , Williams-Beuren syndrome , or Wolf-Hirschhorn syndrome , assessing their intellectual and adaptive behavior abilities . We retested 61 children 2 years later . We compared Time 1 and Time 2 difference scores related to genetic disorder , age , initial IQ , or adaptive behavior composite . Results show genetic disorder and initial IQ score were significant factors for IQ differences , but only genetic disorder affected adaptive behavior differences . Results suggest different gene -brain -behavior pathways likely exist for these genetic disorders . Different developmental trajectories will influence the type and intensity of intervention implemented by caregivers .

Diseases
Validation

Diseases presenting "intellectual disability" symptom

22q11.2 deletion syndrome

alexander disease

alpha-thalassemia

aniridia

child syndrome

cohen syndrome

cowden syndrome

hirschsprung disease

homocystinuria without methylmalonic aciduria

hydrocephalus with stenosis of the aqueduct of sylvius

kabuki syndrome

kallmann syndrome

monosomy 21

oculocutaneous albinism

oligodontia

phenylketonuria

proteus syndrome

triple a syndrome

wolf-hirschhorn syndrome

This symptom has already been validated