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Circulating levels of miR-133a predict the regression potential of left ventricular hypertrophy after valve replacement surgery in patients with aortic stenosis.
[wolf-hirschhorn syndrome]
Myocardial
microRNA-
133
a
(
miR-
133
a
)
is
directly
related
to
reverse
remodeling
after
pressure
overload
release
in
aortic
stenosis
patients
.
Herein
,
we
assessed
the
significance
of
plasma
miR-
133
a
as
an
accessible
biomarker
with
prognostic
value
in
predicting
the
reversibility
potential
of
LV
hypertrophy
after
aortic
valve
replacement
(
AVR
)
in
these
patients
.
The
expressions
of
miR-
133
a
and
its
targets
were
measured
in
LV
biopsies
from
74
aortic
stenosis
patients
.
Circulating
miR-
133
a
was
measured
in
peripheral
and
coronary
sinus
blood
.
LV
mass
reduction
was
determined
echocardiographically
.
Myocardial
and
plasma
levels
of
miR-
133
a
correlated
directly
(
r
=
0
.
46
,
P
<
0
.
001
)
supporting
the
myocardium
as
a
relevant
source
of
plasma
miR-
133
a
.
Accordingly
,
a
significant
gradient
of
miR-
133
a
was
found
between
coronary
and
systemic
venous
blood
.
The
preoperative
plasma
level
of
miR-
133
a
was
higher
in
the
patients
who
normalized
LV
mass
1
year
after
AVR
than
in
those
exhibiting
residual
hypertrophy
.
Logistic
regression
analysis
identified
plasma
miR-
133
a
as
a
positive
predictor
of
the
hypertrophy
reversibility
after
surgery
.
The
discrimination
of
the
model
yielded
an
area
under
the
receiver
operator
characteristic
curve
of
0
.
89
(
P
<
0
.
001
)
.
Multiple
linear
regression
analysis
revealed
plasma
miR-
133
a
and
its
myocardial
target
Wolf-
Hirschhorn
syndrome
candidate
2
/
Negative
elongation
factor
A
as
opposite
predictors
of
the
LV
mass
loss
(
g
)
after
AVR
.
Preoperative
plasma
levels
of
miR-
133
a
reflect
their
myocardial
expression
and
predict
the
regression
potential
of
LV
hypertrophy
after
AVR
.
The
value
of
this
bedside
information
for
the
surgical
timing
,
particularly
in
asymptomatic
aortic
stenosis
patients
,
deserves
confirmation
in
further
clinical
studies
.
Diseases
Validation
Diseases presenting
"aortic stenosis"
symptom
22q11.2 deletion syndrome
oligodontia
wolf-hirschhorn syndrome
This symptom has already been validated
