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Wolf-Hirschhorn syndrome (WHS) - literature review on the features of the syndrome.
[wolf-hirschhorn syndrome]
Wolf-
Hirschhorn
syndrome
(
WHS
)
is
a
congenital
disorder
associated
with
4
chromosome
microdeletion
.
The
patients
suffer
from
various
deformities
.
Among
them
,
mental
and
growth
retardation
,
even
in
the
fetus
,
are
observed
.
Most
of
the
characteristics
concern
facial
features
.
The
"
Greek
warrior
helmet
appearance
"
is
the
most
characteristic
feature
and
refers
to
the
facial
view
with
prominent
glabella
,
high
arched
eyebrow
,
broad
nasal
bridge
and
hypertelorism
.
Another
characteristic
feature
is
microcephalia
with
micrognathia
.
The
features
are
more
pronounced
in
infants
.
Clefts
of
lip
and
/
or
palate
are
observed
in
almost
half
of
the
cases
.
The
characteristic
thing
is
that
the
more
genetic
material
is
missing
,
the
more
pronounced
are
the
dimorphic
features
of
the
syndrome
.
Mostly
,
the
dental
status
does
not
differ
much
from
that
of
the
healthy
individuals
.
It
had
been
proven
though
that
WHS-patients
are
more
prone
to
anomalies
in
dental
structures
.
Cone-shaped
and
taurodontic
teeth
were
observed
.
Multiple
tooth
agenesis
(
mainly
at
premolars
and
molars
)
with
over-retained
deciduous
dentition
might
be
associated
with
MSX
1
-
gene
impairment
.
Diseases
Validation
Diseases presenting
"prominent glabella"
symptom
wolf-hirschhorn syndrome
This symptom has already been validated