Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Urokinase-type plasminogen activator expression and Rac1/WAVE-2/Arp2/3 pathway are blocked by pterostilbene to suppress cell migration and invasion in MDA-MB-231 cells.
[wiskott-aldrich syndrome]
Breast
cancer
is
the
most
common
malignancy
among
females
,
and
cancer
invasion
and
metastasis
are
the
leading
causes
of
cancer
death
in
breast
cancer
patients
.
Pterostilbene
,
a
naturally
occurring
dimethylether
analogue
of
resveratrol
,
has
been
demonstrated
to
possess
anti-
cancer
effects
.
However
,
inhibitory
effects
of
pterostilbene
on
cell
migration
and
invasion
and
its
underlying
mechanisms
are
not
fully
understood
.
In
this
study
,
we
investigated
the
anti-invasive
mechanisms
of
pterostilbene
in
human
breast
cancer
cell
line
MDA-
MB
-
231
cells
.
Pterostilbene
effectively
inhibited
serum-induced
migration
and
invasion
without
affecting
the
viability
of
breast
cancer
cells
.
The
mRNA
expression
and
activity
of
urokinase-
type
plasminogen
activator
(
uPA
)
were
markedly
reduced
by
pterostilbene
treatment
.
Moreover
,
pterostilbene
attenuated
nuclear
factor
κB
(
NF-κB
)
transcriptional
activity
and
DNA
binding
of
NF-κB
on
uPA
promoter
.
In
addition
,
pterostilbene
significantly
impaired
the
activity
of
Rac
1
and
the
expression
of
WASP-family
verprolin-homologous
protein-
2
(
WAVE-
2
)
and
actin-related
protein
2
/
3
(
Arp
2
/
3
)
.
Overall
,
these
results
suggest
that
pterostilbene
caused
considerable
suppression
of
cell
migration
and
invasion
through
blocking
NF-κB-mediated
uPA
expression
and
Rac
1
/
WAVE
/
Arp
2
/
3
pathway
.
Diseases
Validation
Diseases presenting
"breast cancer"
symptom
acute rheumatic fever
aromatase deficiency
carcinoma of the gallbladder
child syndrome
cowden syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
esophageal squamous cell carcinoma
junctional epidermolysis bullosa
kindler syndrome
liposarcoma
lymphangioleiomyomatosis
oral submucous fibrosis
proteus syndrome
severe combined immunodeficiency
systemic capillary leak syndrome
von hippel-lindau disease
waldenström macroglobulinemia
werner syndrome
wiskott-aldrich syndrome
This symptom has already been validated
