Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Antibiotic prophylaxis in primary immune deficiency disorders.
[wiskott-aldrich syndrome]
Long
-term
prophylactic
antibiotics
are
being
widely
implemented
as
primary
or
adjunctive
therapy
in
primary
immune
deficiencies
.
This
practice
has
transformed
clinical
outcomes
in
the
setting
of
chronic
granulomatous
disease
,
complement
deficiencies
,
Mendelian
susceptibility
to
mycobacterial
disease
,
Wiskott-
Aldrich
syndrome
,
hyper-
IgE
syndrome
,
Toll
signaling
defects
,
and
prevented
Pneumocystis
in
patients
with
T
-
cell
deficiencies
.
Yet
,
controlled
trials
are
few
in
the
context
of
primary
antibody
deficiency
syndromes
,
and
most
of
this
practice
has
been
extrapolated
from
data
in
patients
who
are
immune
competent
and
with
recurrent
acute
otitis
media
,
chronic
rhinosinusitis
,
cystic
fibrosis
,
and
bronchiectasis
.
The
paucity
of
guidelines
on
the
subject
is
reflected
in
recent
surveys
among
practicing
immunologists
that
highlight
differences
of
habit
regarding
this
treatment
.
Such
discrepancies
reinforce
the
lack
of
standard
protocols
on
the
subject
.
This
review
will
provide
evidence
for
the
use
of
antibiotic
prophylaxis
in
various
primary
immune
deficiency
populations
,
especially
highlighting
the
role
antibiotic
prophylaxis
in
primary
antibody
deficiency
syndromes
.
We
also
discussed
the
relationship
of
long
-term
antibiotic
use
and
the
prevalence
of
resistant
pathogens
.
Overall
,
examination
of
available
data
on
the
use
of
prophylactic
antibiotics
in
antibody
deficiency
syndromes
merit
future
investigation
in
well-designed
multicenter
prospective
trials
because
this
population
has
few
other
management
options
.
Diseases
Validation
Diseases presenting
"complement deficiencies"
symptom
wiskott-aldrich syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom