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Down-regulation of WAVE2, WASP family verprolin-homologous protein 2, in gastric cancer indicates lymph node metastasis and cell migration.
[wiskott-aldrich syndrome]
WAVE
2
plays
a
crucial
role
in
actin
polymerisation
and
cell
migration
.
We
aimed
to
investigate
the
expression
and
cellular
functions
of
WAVE
2
in
human
gastric
cancer
(
GC
)
.
The
level
of
WAVE
2
was
determined
using
quantitative
PCR
(
Q-PCR
)
in
a
cohort
of
human
gastric
tissues
.
Expression
of
WAVE
2
,
ARP
2
,
NWASP
,
ROCK
1
and
ROCK
2
was
examined
using
RT-PCR
in
paired
tissues
.
WAVE
2
and
ARP
2
protein
co
-expression
was
examined
.
Anti-
WAVE
2
transgene
ribozymes
were
constructed
and
transiently
transfected
into
human
GC
cells
.
Down-regulation
of
WAVE
2
expression
in
GC
was
significantly
correlated
with
lymph
node
metastasis
.
WAVE
2
was
positively
correlated
with
E
-
cadherin
and
negatively
with
TWIST
.
Immunohistochemically
,
WAVE
2
and
ARP
2
were
not
co
-expressed
in
serial
mirror
sections
.
In
vitro
,
WAVE
2
knockdown
was
shown
to
increase
cell
motility
,
whilst
ROCK
inhibitor
treatment
reduced
this
effect
in
HGC
27
cells
.
W
AVE
2
is
down-regulated
in
GC
and
loses
its
metastatic
role
in
GC
.
Knockdown
of
WAVE
2
could
increase
metastatic
potential
by
promoting
the
growth
,
invasiveness
,
motility
,
adhesiveness
and
suppressing
EMT
(
epithelial-mesenchymal
transition
)
of
GC
cells
.
Diseases
Validation
Diseases presenting
"human gastric tissues"
symptom
wiskott-aldrich syndrome
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