Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.
[wiskott-aldrich syndrome]
Phospholipase
D
(
PLD
)
enzymes
play
a
double
vital
role
in
cells
:
they
maintain
the
integrity
of
cellular
membranes
and
they
participate
in
cell
signaling
including
intracellular
protein
trafficking
,
cytoskeletal
dynamics
,
cell
migration
,
and
cell
proliferation
.
The
particular
involvement
of
PLD
in
cell
migration
is
accomplished
:
(
a
)
through
the
actions
of
its
enzymatic
product
of
reaction
,
phosphatidic
acid
,
and
its
unique
shape-binding
role
on
membrane
geometry
;
(
b
)
through
a
particular
guanine
nucleotide
exchange
factor
(
GEF
)
activity
(
the
first
of
its
class
assigned
to
a
phospholipase
)
in
the
case
of
the
mammalian
isoform
PLD
2
;
and
(
c
)
through
protein-protein
interactions
with
a
wide
network
of
molecules
:
Wiskott-
Aldrich
syndrome
protein
(
WASp
)
,
Grb
2
,
ribosomal
S
6
kinase
(
S
6
K
)
,
and
Rac
2
.
Further
,
PLD
interacts
with
a
variety
of
kinases
(
PKC
,
FES
,
EGF
receptor
(
EGFR
)
,
and
JAK
3
)
that
are
activated
by
it
,
or
PLD
becomes
the
target
substrate
.
Out
of
these
myriads
of
functions
,
PLD
is
becoming
recognized
as
a
major
player
in
cell
migration
,
cell
invasion
,
and
cancer
metastasis
.
This
is
the
story
of
the
evolution
of
PLD
from
being
involved
in
a
large
number
of
seemingly
unrelated
cellular
functions
to
its
most
recent
role
in
cancer
signaling
,
a
subfield
that
is
expected
to
grow
exponentially
.
Diseases
Validation
Diseases presenting
"wide network"
symptom
wiskott-aldrich syndrome
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom