Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Expression of Neural Wiskott-Aldrich Syndrome Protein in Clear Cell Renal Cell Carcinoma and Its Correlation with Clinicopathological Features.
[wiskott-aldrich syndrome]
Introduction
:
Neural
Wiskott-
Aldrich
syndrome
protein
(
N-WASP
)
expression
is
associated
with
tumor
cell
invasion
and
migration
.
However
,
its
expression
status
in
clear
cell
renal
cell
carcinoma
(
CCRCC
)
remains
unclear
.
We
examined
the
level
of
N-WASP
in
CCRCC
and
its
association
with
clinicopathological
features
characteristic
.
Materials
and
Methods
:
73
CCRCC
patients
who
underwent
radical
nephrectomy
or
partial
nephrectomy
were
enrolled
.
Immunohistochemical
staining
for
N-WASP
was
performed
on
tissue
microarrays
constructed
from
tumor
and
para-
tumor
tissue
obtained
from
these
patients
.
The
difference
in
N-WASP
expression
between
tumor
tissue
and
adjacent
normal
renal
tissue
was
examined
.
Correlations
between
N-WASP
expression
in
the
tumor
and
clinicopathological
parameters
were
analyzed
and
the
relationship
between
N-WASP
expression
and
overall
survival
also
assessed
.
Uni-
and
multivariate
survival
analyses
were
performed
.
Results
:
N-WASP
expression
was
significantly
reduced
in
tumor
tissues
and
was
significantly
related
to
the
histological
grade
of
CCRCC
.
A
higher
level
of
N-WASP
expression
in
the
tumor
was
associated
with
relatively
poor
survival
in
CCRCC
patients
.
The
level
of
N-WASP
expression
,
age
at
time
of
surgery
,
and
histological
grade
were
all
responsible
for
clinical
outcome
in
CCRCC
patients
.
N-WASP
was
an
independent
predictor
for
overall
survival
.
Conclusions
:
N-WASP
was
downregulated
in
CCRCC
and
could
serve
as
a
prognostic
biomarker
for
predicting
clinical
outcome
of
CCRCC
.
©
2014
S
.
Karger
AG
,
Basel
.