Rare Diseases Symptoms Automatic Extraction
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Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton.
[wiskott-aldrich syndrome]
Ena
/
VASP
proteins
and
the
WAVE
regulatory
complex
(
WRC
)
regulate
cell
motility
by
virtue
of
their
ability
to
independently
promote
actin
polymerization
.
We
demonstrate
that
Ena
/
VASP
and
the
WRC
control
actin
polymerization
in
a
cooperative
manner
through
the
interaction
of
the
Ena
/
VASP
EVH
1
domain
with
an
extended
proline
rich
motif
in
Abi
.
This
interaction
increases
cell
migration
and
enables
VASP
to
cooperatively
enhance
WRC
stimulation
of
Arp
2
/
3
complex
-mediated
actin
assembly
in
vitro
in
the
presence
of
Rac
.
Loss
of
this
interaction
in
Drosophila
macrophages
results
in
defects
in
lamellipodia
formation
,
cell
spreading
,
and
redistribution
of
Ena
to
the
tips
of
filopodia-like
extensions
.
Rescue
experiments
of
abi
mutants
also
reveals
a
physiological
requirement
for
the
Abi
:
Ena
interaction
in
photoreceptor
axon
targeting
and
oogenesis
.
Our
data
demonstrate
that
the
activities
of
Ena
/
VASP
and
the
WRC
are
intimately
linked
to
ensure
optimal
control
of
actin
polymerization
during
cell
migration
and
development
.
