Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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Aberrant DNA methylation profiles in the premature aging disorders Hutchinson-Gilford Progeria and Werner syndrome.
[werner syndrome]
DNA
methylation
gradiently
changes
with
age
and
is
likely
to
be
involved
in
aging-related
processes
with
subsequent
phenotype
changes
and
increased
susceptibility
to
certain
diseases
.
The
Hutchinson
-
Gilford
Progeria
(
HGP
)
and
Werner
Syndrome
(
WS
)
are
two
premature
aging
diseases
showing
features
of
common
natural
aging
early
in
life
.
Mutations
in
the
LMNA
and
WRN
genes
were
associated
to
disease
onset
;
however
,
for
a
subset
of
patients
the
underlying
causative
mechanisms
remain
elusive
.
We
aimed
to
evaluate
the
role
of
epigenetic
alteration
on
premature
aging
diseases
by
performing
comprehensive
DNA
methylation
profiling
of
HGP
and
WS
patients
.
We
observed
profound
changes
in
the
DNA
methylation
landscapes
of
WRN
and
LMNA
mutant
patients
,
which
were
narrowed
down
to
a
set
of
aging
related
genes
and
processes
.
Although
of
low
overall
variance
,
non-mutant
patients
revealed
differential
DNA
methylation
at
distinct
loci
.
Hence
,
we
propose
DNA
methylation
to
have
an
impact
on
premature
aging
diseases
.