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Estrogen and adiposity--utilizing models of aromatase deficiency to explore the relationship.
[aromatase deficiency]
Estrogen
has
an
important
role
to
play
in
energy
homeostasis
in
both
men
and
mice
.
Lack
of
estrogen
results
in
the
development
of
a
metabolic
syndrome
in
humans
and
rodents
,
including
excess
adiposity
,
hepatic
steatosis
(
in
male
but
not
female
aromatase
knockout
(
ArKO
)
mice
)
and
insulin
resistance
.
Estrogen
replacement
results
in
a
prompt
reversal
of
the
energy
imbalance
symptoms
associated
with
estrogen
deficiency
.
A
corollary
to
the
perturbed
energy
balance
observed
in
the
ArKO
mouse
is
the
death
by
apoptosis
of
dopaminergic
neurons
in
the
hypothalamic
arcuate
nucleus
of
male
ArKO
mice
,
an
area
of
the
brain
pivotal
to
the
regulation
of
energy
uptake
,
storage
,
and
mobilisation
.
An
extension
of
our
work
exploring
the
relationship
between
estrogen
and
adiposity
has
been
to
examine
the
role
played
by
androgens
in
energy
balance
.
We
have
demonstrated
that
an
increased
androgen
to
estrogen
ratio
can
promote
visceral
fat
accumulation
in
the
rodent
by
inhibiting
AMPK
activation
and
stimulating
lipogenesis
.
Therefore
,
understanding
the
regulation
of
energy
homeostasis
is
becoming
an
increasingly
fascinating
challenge
,
as
the
number
of
contributors
,
their
communications
,
and
the
complexity
of
their
interactions
,
involved
in
the
preservation
of
this
equilibrium
continues
to
increase
.
Models
of
aromatase
deficiency
,
both
naturally
occurring
and
engineered
,
will
continue
to
provide
valuable
insights
into
energy
homeostasis
.
Diseases
Validation
Diseases presenting
"not female aromatase knockout"
symptom
aromatase deficiency
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