Rare Diseases Symptoms Automatic Extraction

Small molecule inhibition of p38 MAP kinase extends the replicative life span of human ATR-Seckel syndrome fibroblasts.

[werner syndrome]

Ataxia-telangiectasia and rad3 (ATR)-related Seckel syndrome is associated with growth retardation and premature aging features. ATR-Seckel fibroblasts have a reduced replicative capacity in vitro and an aged morphology that is associated with activation of stress-associated p38 mitogen-activated protein kinase and phosphorylated HSP27. These phenotypes are prevented using p38 inhibitors, with replicative capacity restored to the normal range. However, this stressed phenotype is retained in telomerase-immortalized ATR-Seckel fibroblasts, indicating that it is independent of telomere erosion. As with normal fibroblasts, senescence in ATR-Seckel is bypassed by p53 abrogation. Young ATR-Seckel fibroblasts show elevated levels of p21(WAF1), p16(INK4A), phosphorylated actin-binding protein cofilin, and phosphorylated caveolin-1, with small molecule drug inhibition of p38 reducing p16(INK4A) and caveolin-1 phosphorylation. In conclusion, ATR-Seckel fibroblasts undergo accelerated aging via stress-induced premature senescence and p38 activation that may underlie certain clinical features of Seckel syndrome, and our data suggest a novel target for pharmacological intervention in this human syndrome.

Diseases presenting "telangiectasia" symptom

  • coats disease
  • cowden syndrome
  • cutaneous mastocytosis
  • hereditary cerebral hemorrhage with amyloidosis
  • kallmann syndrome
  • kindler syndrome
  • malignant atrophic papulosis
  • omenn syndrome
  • pendred syndrome
  • severe combined immunodeficiency
  • systemic capillary leak syndrome
  • triple a syndrome
  • waldenström macroglobulinemia
  • werner syndrome

This symptom has already been validated