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Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~2008).
[werner syndrome]
As
~
75
%
of
the
Werner
syndrome
(
WS
)
patients
recognized
between
1904
and
2008
all
over
the
world
are
of
Japanese
origin
,
the
most
case
reports
and
clinical
studies
on
WS
has
been
published
in
Japanese
journals
.
Thus
,
the
detailed
English
-written
clinical
review
on
the
recent
WS
case
reports
has
been
warranted
.
Although
WS
has
been
characterized
by
a
variety
of
clinical
manifestations
mimicking
premature
aging
,
the
recent
longevity
and
delayed
age-associated
manifestations
observed
both
from
Japanese
WS
and
general
population
may
suggest
a
common
environmental
effect
on
some
gene
(
s
)
other
than
WRN
and
may
give
us
a
newer
pathophysiological
look
at
WS
and
also
natural
aging
through
the
molecular
dysfunction
of
WRN
.