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A random Abstract
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Role of DNA damage in cardiovascular disease.
[werner syndrome]
Patients
with
some
progeroid
syndromes
,
such
as
Werner
syndrome
,
exhibit
atherosclerotic
cardiovascular
disease
(
CVD
)
at
a
young
age
as
a
manifestation
of
premature
aging
.
Recent
studies
have
revealed
that
most
progeroid
syndromes
are
caused
by
genetic
defects
in
specific
molecules
involved
in
the
DNA
damage
response
,
a
cornerstone
of
genome
stability
.
Ionizing
radiation
is
one
of
the
most
potent
genotoxic
stimuli
and
causes
various
kinds
of
DNA
damage
.
Further
,
there
is
increasing
evidence
that
therapeutic
radiation
treatments
can
cause
cardiovascular
complications
.
Here
,
we
describe
the
DNA
damage
and
subsequent
response
,
review
recent
advances
in
the
understanding
of
the
molecular
basis
of
progeroid
syndromes
(
especially
those
syndromes
that
involve
CVD
)
,
review
the
pathological
and
epidemiological
analysis
of
radiation-induced
CVD
,
and
discuss
the
possible
role
of
DNA
damage
and
the
DNA
damage
response
in
the
pathogenesis
of
atherosclerotic
CVD
.
