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WRNIP1 functions upstream of DNA polymerase η in the UV-induced DNA damage response.
[werner syndrome]
WRNIP
1
(
WRN
-interacting
protein
1
)
was
first
identified
as
a
factor
that
interacts
with
WRN
,
the
protein
that
is
defective
in
Werner
syndrome
(
WS
)
.
WRNIP
1
associates
with
DNA
polymerase
η
(
Pol
η
)
,
but
the
biological
significance
of
this
interaction
remains
unknown
.
In
this
study
,
we
analyzed
the
functional
interaction
between
WRNIP
1
and
Pol
η
by
generating
knockouts
of
both
genes
in
DT
40
chicken
cells
.
Disruption
of
WRNIP
1
in
Pol
η-disrupted
(
POLH
(
-
/
-
)
)
cells
suppressed
the
phenotypes
associated
with
the
loss
of
Pol
η
:
sensitivity
to
ultraviolet
light
(
UV
)
,
delayed
repair
of
cyclobutane
pyrimidine
dimers
(
CPD
)
,
elevated
frequency
of
mutation
,
elevated
levels
of
UV-induced
sister
chromatid
exchange
(
SCE
)
,
and
reduced
rate
of
fork
progression
after
UV
irradiation
.
These
results
suggest
that
WRNIP
1
functions
upstream
of
Pol
η
in
the
response
to
UV
irradiation
.
Diseases
Validation
Diseases presenting
"elevated levels"
symptom
22q11.2 deletion syndrome
adrenal incidentaloma
adrenomyeloneuropathy
alexander disease
aniridia
cadasil
canavan disease
congenital adrenal hyperplasia
epidermolysis bullosa simplex
erythropoietic protoporphyria
esophageal carcinoma
fabry disease
familial hypocalciuric hypercalcemia
hereditary cerebral hemorrhage with amyloidosis
inclusion body myositis
kabuki syndrome
omenn syndrome
phenylketonuria
primary effusion lymphoma
pyruvate dehydrogenase deficiency
scrub typhus
sneddon syndrome
werner syndrome
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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