Rare Diseases Symptoms Automatic Extraction
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A random Abstract
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WRNIP1 functions upstream of DNA polymerase η in the UV-induced DNA damage response.
[werner syndrome]
WRNIP
1
(
WRN
-interacting
protein
1
)
was
first
identified
as
a
factor
that
interacts
with
WRN
,
the
protein
that
is
defective
in
Werner
syndrome
(
WS
)
.
WRNIP
1
associates
with
DNA
polymerase
η
(
Pol
η
)
,
but
the
biological
significance
of
this
interaction
remains
unknown
.
In
this
study
,
we
analyzed
the
functional
interaction
between
WRNIP
1
and
Pol
η
by
generating
knockouts
of
both
genes
in
DT
40
chicken
cells
.
Disruption
of
WRNIP
1
in
Pol
η-disrupted
(
POLH
(
-
/
-
)
)
cells
suppressed
the
phenotypes
associated
with
the
loss
of
Pol
η
:
sensitivity
to
ultraviolet
light
(
UV
)
,
delayed
repair
of
cyclobutane
pyrimidine
dimers
(
CPD
)
,
elevated
frequency
of
mutation
,
elevated
levels
of
UV-induced
sister
chromatid
exchange
(
SCE
)
,
and
reduced
rate
of
fork
progression
after
UV
irradiation
.
These
results
suggest
that
WRNIP
1
functions
upstream
of
Pol
η
in
the
response
to
UV
irradiation
.
