Transient overexpression of Werner protein rescues starvation induced autophagy in Werner syndrome cells.

[werner syndrome]

Reduced autophagy may be associated with normal and pathological aging . Here we report a link between autophagy and Werner protein (WRNp ), mutated in Werner syndrome , the human premature aging Werner syndrome (WS ). WRN mutant fibroblast AG 11395 and AG 05229 respond weakly to starvation induced autophagy compared to normal cells . While the fusion of phagosomes with lysosome is normal , WS cells contain fewer autophagy vacuoles . Cellular starvation autophagy in WS cells is restored after transfection with full length WRN . Further , siRNA mediated silencing of WRN in the normal fibroblast cell line WI -38 results in decreased autophagy and altered expression of autophagy related proteins . Thus , our observations suggest that WRN may have a role in controlling autophagy and hereby cellular maintenance .

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werner syndrome

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