Testosterone action on erythropoiesis does not require its aromatization to estrogen: Insights from the testosterone and estrogen treatment of two aromatase-deficient men.

[aromatase deficiency]

Androgens act on erythropoiesis , but the relative role of testosterone (T ) and estradiol (E (2 )) on erythropoietic parameters in men is a poorly investigated issue . In order to evaluate separately the effects on erythropoiesis of high -dose T administration alone and of physiological dose of E (2 ) administration alone two adult men with aromatase deficiency were assessed before and during each treatment . Blood cell count , hemoglobin (Hb ), hematocrit (Hct ), erythrocyte mean cell volume (MCV ), erythrocyte mean corpuscular hemoglobin (MCH ), erythrocyte mean corpuscular hemoglobin concentration (MCHC ), serum ferritin , iron and total iron -binding capacity (TIBC ), serum erythropoietin , serum total testosterone and estradiol were evaluated . Hb , Hct and red cell count rose during testosterone treatment , consistently with the increase in circulating testosterone , but failed to increase during estradiol treatment . A decrease in Hb , Hct and red cell count was recorded in one of the two subjects during estradiol treatment , with a concomitant decrease in serum testosterone . Circulating T alone is capable of and sufficient to influence erythropoiesis , especially at supraphysiological dosage , while circulating E (2 ) have not the same effect on erythropoietic parameters , suggesting the hypothesis that the erythropoietic changes induced by androgens are not mediated via its aromatization to estrogens .

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Diseases presenting "poorly investigated issue" symptom

aromatase deficiency

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