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Giant gastric lipoma mimicking well-differentiated liposarcoma.
[well-differentiated liposarcoma]
Authors
report
the
case
of
a
51
-
year
-old
man
,
presenting
with
epigastralgia
of
recent
onset
.
Physical
exam
was
unremarkable
.
Endoscopy
revealed
a
large
,
ulcerated
,
submucosal
,
antral
tumor
.
CT
scan
reveals
an
antral
mass
with
fat
attenuation
.
The
patient
underwent
a
total
gastrectomy
.
Macroscopic
examination
identified
in
the
antral
wall
a
9
-
cm
,
well-circumscribed
,
nodular
lesion
,
with
a
yellow
,
greasy
cut
surface
.
On
histological
examination
,
the
tumor
was
composed
of
a
mature
adipocytes
proliferation
,
showing
significant
variation
in
cell
size
,
associated
to
some
lipoblasts
.
Nuclei
were
sometimes
large
,
slightly
irregular
,
but
without
hyperchromasia
nor
mitosis
.
Diagnosis
of
a
well-differentiated
liposarcoma
was
suspected
and
molecular
cytogenetic
analyses
showed
no
MDM
2
nor
CDK
4
gene
amplification
on
fluorescent
in
situ
hybridization
.
The
diagnosis
of
lipoma
was
made
.
Twelve
months
following
surgery
,
the
patient
is
doing
well
.
Diseases
Validation
Diseases presenting
"nodular lesion"
symptom
well-differentiated liposarcoma
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