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Long-lasting clinical benefit of sunitinib malate in the treatment of a case of heavily pre-treated metastatic liposarcoma.
[well-differentiated liposarcoma]
Soft
tissue
sarcomas
are
a
heterogeneous
group
of
malignant
neoplasms
including
several
distinct
entities
with
different
cell
differentiation
and
clinical
prognosis
,
but
which
are
often
treated
as
a
single
disease
.
We
report
the
case
of
a
male
patient
,
heavily
treated
for
a
metastatic
well-differentiated
liposarcoma
occurring
in
the
left
lateral
neck
.
He
received
radiotherapy
and
different
lines
of
standard
chemotherapy
with
local
progression
and
lung
metastasis
.
In
November
2009
,
on
the
basis
of
a
phase
II
study
demonstrating
the
efficacy
of
sunitinib
in
patients
with
liposarcoma
,
the
patient
was
treated
with
sunitinib
at
37
.
5
mg
daily
in
4
-
week
cycles
on
a
compassionate
use
basis
.
Until
November
2012
he
received
a
total
of
23
cycles
of
sunitinib
treatment
achieving
a
stable
disease
in
all
sites
.
Therapy
with
sunitinib
is
still
ongoing
without
side
effects
.
Our
findings
confirm
that
sunitinib
may
be
a
useful
therapeutic
tool
in
the
treatment
of
some
cases
of
pre-treated
liposarcoma
.
