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A case of well-differentiated palpebral liposarcoma in a Guinea pig (Cavia porcellus).
[well-differentiated liposarcoma]
Liposarcomas
are
rare
malignant
tumors
of
the
adipose
tissue
which
are
well
described
in
humans
and
animals
.
Wide
margin
excision
is
the
recommended
treatment
for
these
infiltrative
,
slow
to
metastasize
tumors
.
Primary
liposarcoma
with
ocular
localization
is
a
very
rare
tumor
in
humans
,
dogs
and
cats
.
This
report
describes
,
for
the
first
time
,
a
palpebral
liposarcoma
in
a
18
-
month
old
guinea
pig
that
presented
with
a
large
palpebral
mass
and
purulent
discharge
in
the
right
eye
.
The
ophthalmic
evaluation
revealed
a
one
-centimeter
infiltrating
subcutaneous
mass
within
the
upper
eyelid
,
a
severe
chemosis
and
hyperhemia
of
the
palpebral
and
bulbar
conjunctiva
of
the
right
eye
.
Cytologic
examination
of
the
mass
revealed
only
epithelial
cells
.
Histologic
examination
interpreted
the
lesion
as
a
xanthogranulomatous
reaction
possibly
secondary
to
meibomian
gland
rupture
or
inflammation
.
One
month
later
,
the
mass
had
increased
in
size
and
the
animal
had
stopped
eating
.
Euthanasia
was
performed
and
a
large
biopsy
was
submitted
for
another
histological
examination
.
Histopathology
revealed
polygonal
to
rounded
cells
with
a
large
,
empty
intracytoplasmic
vacuole
,
and
an
ovoid
,
eccentrically
located
nucleus
.
The
histology
was
consistent
with
a
well-differentiated
liposarcoma
.
Given
the
unusual
location
,
immunohistochemistry
was
performed
to
ascertain
the
mesenchymal
nature
of
the
neoplasm
.
Diseases
Validation
Diseases presenting
"neoplasm"
symptom
adrenal incidentaloma
alexander disease
aromatase deficiency
carcinoma of the gallbladder
cholangiocarcinoma
cowden syndrome
cushing syndrome
cutaneous mastocytosis
dedifferentiated liposarcoma
dentin dysplasia
erdheim-chester disease
esophageal adenocarcinoma
esophageal carcinoma
familial hypocalciuric hypercalcemia
focal myositis
hodgkin lymphoma, classical
hydrocephalus with stenosis of the aqueduct of sylvius
junctional epidermolysis bullosa
kabuki syndrome
liposarcoma
lymphangioleiomyomatosis
pleomorphic liposarcoma
primary effusion lymphoma
proteus syndrome
pyomyositis
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
werner syndrome
wolf-hirschhorn syndrome
This symptom has already been validated