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Sclerosing variant of well-differentiated liposarcoma: relative prevalence and spectrum of CT and MRI features.
[well-differentiated liposarcoma]
The
purpose
of
this
study
was
to
determine
the
relative
prevalence
of
the
sclerosing
variant
of
well-differentiated
liposarcoma
at
one
institution
and
to
elucidate
the
CT
and
MRI
characteristics
of
this
subtype
of
well-differentiated
liposarcoma
.
A
retrospective
computerized
search
was
conducted
to
calculate
the
relative
prevalence
of
the
sclerosing
variant
of
well-differentiated
liposarcoma
among
all
well-differentiated
liposarcoma
subtypes
at
one
institution
.
The
MRI
and
CT
features
of
a
total
of
19
cases
of
pathologically
proven
sclerosing
variant
of
well-differentiated
liposarcoma
were
evaluated
(
seven
identified
from
the
study
institution
database
and
12
cases
contributed
by
other
institutions
)
.
The
cases
of
a
total
of
36
patients
with
well-differentiated
liposarcoma
were
identified
in
the
pathology
database
;
six
(
17
%
)
cases
had
evidence
of
dedifferentiation
.
Seven
(
19
%
)
cases
of
sclerosing
variant
of
well-differentiated
liposarcoma
were
identified
.
Of
these
,
three
(
43
%
)
had
evidence
of
dedifferentiation
.
On
images
,
the
sclerosing
variant
of
well-differentiated
liposarcoma
typically
presented
as
a
large
(
average
,
16
.
6
cm
)
well-circumscribed
heterogeneous
mass
most
commonly
situated
in
the
retroperitoneum
(
58
%
)
.
Sixteen
of
the
19
tumors
evaluated
(
84
%
)
had
predominantly
well-circumscribed
margins
.
Tumor
composition
ranged
from
predominantly
fatty
to
entirely
devoid
of
macroscopic
fat
;
only
three
(
16
%
)
were
composed
of
more
than
75
%
fat
.
Variable
amounts
of
nonlipomatous
elements
were
identified
in
all
cases
.
Enhancement
of
these
elements
was
evident
at
CT
or
MRI
in
all
14
cases
in
which
enhancement
could
be
reliably
assessed
.
The
sclerosing
variant
of
well-differentiated
liposarcoma
should
be
included
in
the
differential
diagnosis
of
any
well-circumscribed
lipomatous
mass
containing
variable
amounts
of
nonlipomatous
elements
,
particularly
when
located
in
the
retroperitoneum
.
Unlike
other
subtypes
of
well-differentiated
liposarcoma
,
the
sclerosing
variant
is
less
likely
to
be
composed
predominantly
of
fat
and
may
be
associated
with
an
increased
propensity
for
dedifferentiation
.