Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification.

[well-differentiated liposarcoma]

Liposarcomas are among the most common soft tissue sarcomas in adulthood .The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO ) classification of cases diagnosed with liposarcoma and to examine the difference of p 53 and MDM 2 expressions .The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p 53 and MDM 2 .Chi -Square test was applied .20 subjects were diagnosed with well-differentiated liposarcoma (WLS ), 16 myxoid liposarcoma (ML ), 7 pleomorphic liposarcoma (PL ), and 5 de -differentiated liposarcoma (DLS ). The number of cases stained positive with MDM 2 and p 53 were positive correlated in all subjects (P = 0 .02 ). p 53 and MDM 2 positivity increased in high grade tumors (P = 0 .01 ).p 53 and MDM 2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study .

Diseases
Validation

Diseases presenting "well-differentiated liposarcoma" symptom

dedifferentiated liposarcoma

liposarcoma

pleomorphic liposarcoma

well-differentiated liposarcoma

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