Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors.

[well-differentiated liposarcoma]

Equivalent cross-relaxation rate imaging (ECRI ) is an MRI technique used to evaluate qualitative changes in protein-water interactions . We aimed to prospectively evaluate the utility of ECRI for classification of adipocytic tumors .I nstitutional Review Board approval was obtained and all patients provided informed consent . Study participants included 40 patients with adipocytic tumors who were diagnosed with lipomas (n =22 ), atypical lipomatous tissue /well-differentiated liposarcoma (ALT /WDL ; n =9 ), myxoid /round cell liposarcoma (MyL ; n =6 ), and dedifferentiated liposarcoma (DDL ; n =3 ), and 20 control patients for whom subcutaneous fat in the buttock or thigh was analyzed .Mean ECR values of lipomas , ALT /WDL , and subcutaneous fat were low , and those of MyL and DDL were high . Mean ECR values of MyL and DDL were significantly higher than those of ALT /WDL . The cut-off value was 5 .1 %. There was a positive correlation between ECR value , pathological grade , and cell density in adipocytic tumors .T he ECR value positively correlates with pathological grade and cell density of adipocytic tumors . Our findings suggest that ECRI is a useful method for preoperative evaluation of adipocytic tumors .

Diseases
Validation

Diseases presenting "atypical lipomatous tissue/well-differentiated" symptom

dedifferentiated liposarcoma

well-differentiated liposarcoma

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