Adjuvant radiotherapy for extremity and trunk wall atypical lipomatous tumor/well-differentiated LPS (ALT/WD-LPS): a French Sarcoma Group (GSF-GETO) study.

[well-differentiated liposarcoma]

The role of adjuvant radiotherapy (RT ) in the management of atypical lipomatous tumor /well-differentiated liposarcoma (ALT /WD-LPS ) remains controversial .Two hundred eighty-three patients with operable ALT /WD-LPS , no history of previous cancer , chemotherapy (CT ) or RT , treated between 1984 and 2011 registered in the Conticabase database were included and described . Overall (OS ), progression-free survival (PFS ) and time to local relapse (TTLR ) were evaluated from the time of first treatment .Three of 20 centers enrolled 58 % of the patients . Median age at diagnosis was 61 (range 25 -94 ) years , 147 patients (52 %) were males , 222 (78 %) patients had their primary tumor located in an extremity while 36 (13 %) and 25 (9 %) had tumors involving the girdle and the trunk wall , respectively . The median size of primary tumors was 17 cm (range 2 -48 cm ). Adjuvant RT was given to 132 patients (47 %). Patients who received adjuvant RT had larger tumors (P = 0 .005 ), involving more often the distal limbs (P < 0 .001 ). Use of adjuvant RT varied across centers and along the study period . Other characteristics were balanced between the two groups . Median follow-up was 61 .7 months . None of the patients developed metastasis during follow-up . The 5 -year local relapse-free survival rates were 98 .3 % versus 80 .3 % with and without adjuvant RT , respectively (P < 0 .001 ). Once stratified on time period (before /after 2003 ), adjuvant RT , tumor site and margin status (R 0 versus other ) were independently associated with TTLR . No OS difference was observed (P = 0 .105 ).In this study , adjuvant RT following resection of ALT /WD-LPS was associated with a reduction of LR risk .

Diseases
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Diseases presenting "a reduction of lr risk" symptom

liposarcoma

well-differentiated liposarcoma

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