Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
CDK4 amplification predicts recurrence of well-differentiated liposarcoma of the abdomen.
[well-differentiated liposarcoma]
The
absence
of
CDK
4
amplification
in
liposarcomas
is
associated
with
favorable
prognosis
.
We
aimed
to
identify
the
factors
associated
with
tumor
recurrence
in
patients
with
well-differentiated
(
WD
)
and
dedifferentiated
(
DD
)
liposarcomas
.
From
2000
to
2010
,
surgical
resections
for
101
WD
and
DD
liposarcomas
were
performed
.
Cases
in
which
complete
surgical
resections
with
curative
intent
were
carried
out
were
selected
.
MDM
2
and
CDK
4
gene
amplification
were
analyzed
by
quantitative
real-time
polymerase
chain
reaction
(
Q-PCR
)
.
There
were
31
WD
and
17
DD
liposarcomas
.
Locoregional
recurrence
was
observed
in
11
WD
and
3
DD
liposarcomas
.
WD
liposarcomas
showed
better
patient
survival
compared
to
DD
liposarcomas
(
P
<
0
.
05
)
.
Q-PCR
analysis
of
the
liposarcomas
revealed
the
presence
of
CDK
4
amplification
in
44
cases
(
91
.
7
%
)
and
MDM
2
amplification
in
46
cases
(
95
.
8
%
)
.
WD
liposarcomas
with
recurrence
after
surgical
resection
had
significantly
higher
levels
of
CDK
4
amplification
compared
to
those
without
recurrence
(
P
 
=
 
0
.
041
)
.
High
level
of
CDK
4
amplification
(
cases
with
CDK
4
amplification
higher
than
the
median
7
.
54
)
was
associated
with
poor
recurrence-free
survival
compared
to
low
CDK
4
amplification
in
both
univariate
(
P
 
=
 
0
.
012
)
and
multivariate
analyses
(
P
 
=
 
0
.
020
)
.
Level
of
CDK
4
amplification
determined
by
Q-PCR
was
associated
with
the
recurrence
of
WD
liposarcomas
after
surgical
resection
.
