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Syndecan-1 regulates adipogenesis: new insights in dedifferentiated liposarcoma tumorigenesis.
[well-differentiated liposarcoma]
Syndecan-
1
(
SDC
1
/
CD
138
)
is
one
of
the
main
cell
surface
proteoglycans
and
is
involved
in
crucial
biological
processes
.
Only
a
few
studies
have
analyzed
the
role
of
SDC
1
in
mesenchymal
tumor
pathogenesis
.
In
particular
,
its
involvement
in
adipose
tissue
tumors
has
never
been
investigated
.
Dedifferentiated
liposarcoma
,
one
of
the
most
frequent
types
of
malignant
adipose
tumors
,
has
a
high
potential
of
recurrence
and
metastastic
evolution
.
Classical
chemotherapy
is
inefficient
in
metastatic
dedifferentiated
liposarcoma
and
novel
biological
markers
are
needed
for
improving
its
treatment
.
In
this
study
,
we
have
analyzed
the
expression
of
SDC
1
in
well-differentiated
/
dedifferentiated
liposarcomas
and
showed
that
SDC
1
is
highly
overexpressed
in
dedifferentiated
liposarcoma
compared
to
normal
adipose
tissue
and
lipomas
.
Silencing
of
SDC
1
in
liposarcoma
cells
impaired
cell
viability
and
proliferation
.
Using
the
human
multipotent
adipose-derived
stem
(
hMADS
)
cell
model
of
human
adipogenesis
,
we
showed
that
SDC
1
promotes
proliferation
of
undifferentiated
adipocyte
progenitors
and
inhibits
their
adipogenic
differentiation
.
Altogether
,
our
results
support
the
hypothesis
that
SDC
1
might
be
involved
in
liposarcomagenesis
.
It
might
play
a
prominent
role
in
the
dedifferentiation
process
occurring
when
well-differentiated
liposarcoma
progress
to
dedifferentiated
liposarcoma
.
Targeting
SDC
1
in
these
tumors
might
provide
a
novel
therapeutic
strategy
.
Diseases
Validation
Diseases presenting
"proliferation"
symptom
dedifferentiated liposarcoma
erdheim-chester disease
liposarcoma
well-differentiated liposarcoma
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