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Novel agents in indolent lymphomas.
[waldenström macroglobulinemia]
Indolent
non-
Hodgkin
's
lymphomas
(
iNHLs
)
include
follicular
lymphomas
(
FL
)
,
marginal-zone
lymphoma
,
lymphoplasmacytic
lymphoma
/
Waldenström
macroglobulinemia
and
small
lymphocytic
lymphoma
.
First
-line
standard
therapy
in
advanced
,
symptomatic
iNHL
consists
of
rituximab-based
immunochemotherapy
.
The
recent
rediscovery
of
the
'
old
'
chemotherapeutic
agent
bendamustine
,
an
alkylating
agent
with
a
peculiar
mechanism
of
action
,
has
added
a
new
effective
and
well-tolerated
option
to
the
therapeutic
armamentarium
in
iNHL
,
increasing
response
rates
and
duration
.
However
,
patients
invariably
relapse
and
subsequent
active
and
well-tolerated
agents
are
needed
.
In
recent
years
a
large
number
of
new
targeted
agents
have
been
tested
in
preclinical
and
clinical
experimentation
in
FL
and
indolent
nonfollicular
lymphoma
(
iNFL
)
,
including
the
new
monoclonal
antibodies
binding
CD
2
0
or
other
surface
antigens
,
immunoconjugates
and
bispecific
antibodies
.
Moreover
novel
agents
directed
against
intracellular
processes
such
as
proteasome
inhibitors
,
mTOR
inhibitors
and
agents
that
target
the
tumour
microenvironment
,
notably
the
immunomodulatory
agent
lenalidomide
,
are
under
active
clinical
investigation
.
The
development
of
these
new
drugs
may
change
in
the
near
future
the
approach
to
iNHL
patients
,
leading
to
better
tolerated
and
effective
therapy
regimens
.
Diseases
Validation
Diseases presenting
"large number"
symptom
acute rheumatic fever
adrenal incidentaloma
allergic bronchopulmonary aspergillosis
canavan disease
coats disease
cowden syndrome
dedifferentiated liposarcoma
dracunculiasis
epidermolysis bullosa simplex
fabry disease
familial mediterranean fever
gm1 gangliosidosis
heparin-induced thrombocytopenia
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
kindler syndrome
legionellosis
malignant atrophic papulosis
neuralgic amyotrophy
phenylketonuria
pleomorphic liposarcoma
primary effusion lymphoma
scrub typhus
severe combined immunodeficiency
triple a syndrome
waldenström macroglobulinemia
well-differentiated liposarcoma
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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