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Genetic aberrations of signaling pathways in lymphomagenesis: revelations from next generation sequencing studies.
[waldenström macroglobulinemia]
Next
generation
sequencing
(
NGS
)
technology
has
led
to
a
burst
of
disease-relevant
molecular
information
in
a
variety
of
lymphoid
tumors
,
including
chronic
lymphocytic
leukemia
,
diffuse
large
B-
cell
lymphoma
,
follicular
lymphoma
,
mantle
cell
lymphoma
,
Burkitt
lymphoma
,
Waldenström
macroglobulinemia
,
hairy
cell
leukemia
,
and
splenic
marginal
zone
lymphoma
.
Beside
disclosing
comprehensive
catalogs
of
somatic
mutations
and
new
insights
into
the
genes
that
contribute
to
cellular
transformation
,
NGS
has
also
provided
molecular
clues
useful
for
addressing
a
number
of
unmet
clinical
needs
in
the
field
of
B-
cell
tumor
management
,
including
biomarkers
for
disease
diagnosis
and
classification
improvement
(
i
.
e
.
mutations
of
BRAF
,
MYD
88
and
NOTCH
2
)
,
and
new
targets
to
be
translated
into
therapeutic
interventions
(
i
.
e
.
BCR
,
TLR
,
NOTCH
,
NF-κB
and
MAPK
signaling
pathways
)
.
This
review
summarizes
the
molecular
lesions
of
signaling
pathways
that
have
been
discovered
in
B-
cell
lymphoproliferative
disorders
by
NGS
studies
.
Diseases
Validation
Diseases presenting
"also provided molecular clues"
symptom
waldenström macroglobulinemia
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