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Waldenström's macroglobulinemia associated with serum amyloid A protein amyloidosis: pitfalls in diagnosis and successful treatment with melphalan-based autologous stem cell transplant.
[waldenström macroglobulinemia]
Waldenström
's
macroglobulinemia
(
WM
)
is
increasingly
being
associated
with
amyloidosis
particularly
of
the
amyloid
light-chain
variety
.
We
report
on
one
of
the
few
cases
of
WM
associated
with
serum
amyloid
A
protein
(
AA
)
amyloidosis
.
Autologous
stem
cell
transplant
(
ASCT
)
is
now
being
increasingly
used
for
the
treatment
of
amyloidosis
,
but
most
studies
are
small
case
series
.
Traditionally
AA
amyloid
is
associated
with
connective
tissue
disorders
and
periodic
fever
syndromes
and
has
been
treated
by
addressing
the
underlying
condition
.
We
present
the
first
case
of
serum
amyloid
A
being
treated
with
melphalan-based
ASCT
to
deal
with
the
underlying
WM
and
thereby
control
the
amyloid
,
thus
demonstrating
the
viability
of
this
novel
approach
for
the
treatment
of
this
disorder
.
Diseases
Validation
Diseases presenting
"amyloidosis particularly of the amyloid light-chain variety"
symptom
waldenström macroglobulinemia
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