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Unique association of Waldenström macroglobulinemia with optic neuritis and monoclonal T cell expansion.
[waldenström macroglobulinemia]
Waldenström
macroglobulinemia
is
a
lymphoplasmacytic
lymphoma
characterized
by
production
of
the
immunoglobulin
M
(
IgM
)
monoclonal
protein
.
Commonly
involved
sites
are
the
bone
marrow
,
lymph
nodes
,
and
spleen
.
Lymphoplasmacytic
infiltration
of
the
central
nervous
system
(
CNS
)
,
in
contrast
,
is
referred
to
as
Bing
-
Neel
syndrome
,
and
is
an
extremely
rare
phenomenon
.
Here
,
we
present
a
unique
case
of
Waldenström
macroglobulinemia
with
optic
neuritis
accompanied
by
monoclonal
expansion
of
T
cells
,
which
recovered
after
administration
of
CNS-targeting
chemotherapy
.
Although
the
underlying
causal
relationships
in
this
case
remain
obscure
,
aberrantly
expanded
T
cells
may
have
contributed
to
the
development
of
optic
neuritis
,
and
we
should
be
reminded
that
some
types
of
cranial
neuropathy
in
Waldenström
macroglobulinemia
may
be
reversible
.
Diseases
Validation
Diseases presenting
"central nervous system"
symptom
22q11.2 deletion syndrome
adrenomyeloneuropathy
alexander disease
aniridia
aromatase deficiency
canavan disease
child syndrome
classical phenylketonuria
congenital toxoplasmosis
cowden syndrome
cushing syndrome
cystinuria
dracunculiasis
erdheim-chester disease
fabry disease
gm1 gangliosidosis
hereditary cerebral hemorrhage with amyloidosis
hirschsprung disease
hodgkin lymphoma, classical
kabuki syndrome
kallmann syndrome
kindler syndrome
krabbe disease
lamellar ichthyosis
legionellosis
liposarcoma
malignant atrophic papulosis
monosomy 21
neonatal adrenoleukodystrophy
phenylketonuria
proteus syndrome
scrub typhus
severe combined immunodeficiency
sneddon syndrome
triple a syndrome
von hippel-lindau disease
waldenström macroglobulinemia
well-differentiated liposarcoma
wiskott-aldrich syndrome
wolf-hirschhorn syndrome
x-linked adrenoleukodystrophy
zellweger syndrome
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