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A random Abstract
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Inherited predisposition to multiple myeloma.
[waldenström macroglobulinemia]
Multiple
myeloma
(
MM
)
is
the
second
most
common
hematologic
malignancy
in
the
United
States
,
after
non-
Hodgkin
lymphoma
.
Family
pedigree
analyses
of
high
-risk
families
,
case-control
studies
and
racial
disparities
in
disease
incidence
all
point
to
a
potential
inherited
predisposition
to
MM
.
Genome-
wide
association
studies
(
GWASs
)
have
identified
susceptibility
loci
in
a
number
of
cancers
and
such
studies
are
currently
underway
in
MM
.
To
date
,
GWASs
in
MM
have
identified
several
potential
regions
of
interest
for
further
study
on
chromosomes
3
p
22
,
7
p
15
.
3
,
8
q
24
and
2
p
23
.
3
.
In
addition
,
several
targets
of
paraproteins
(
so
called
'
paratargs
'
)
in
MM
have
been
identified
.
Hyperphosphorylation
of
the
paratarg
protein
,
which
is
inherited
in
an
autosomal
dominant
manner
,
appears
a
common
mechanism
underlying
the
antigenicity
of
these
proteins
.
One
particular
protein
,
hyperphosphorylated
paratarg-
7
(
pP-
7
)
is
a
common
target
in
persons
with
myeloma
and
has
also
been
identified
in
affected
members
of
several
high
-risk
MM
families
.
It
appears
that
the
frequency
of
pP-
7
as
an
antigenic
target
may
be
particularly
high
in
African
American
patients
with
MM
,
which
could
be
part
of
the
explanation
for
observed
racial
disparities
in
the
incidence
of
MM
.
In
this
review
we
focus
on
available
data
in
the
area
of
inherited
predisposition
to
MM
,
and
highlight
future
research
directions
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated