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Inherited predisposition to multiple myeloma.
[waldenström macroglobulinemia]
Multiple
myeloma
(
MM
)
is
the
second
most
common
hematologic
malignancy
in
the
United
States
,
after
non-
Hodgkin
lymphoma
.
Family
pedigree
analyses
of
high
-risk
families
,
case-control
studies
and
racial
disparities
in
disease
incidence
all
point
to
a
potential
inherited
predisposition
to
MM
.
Genome-
wide
association
studies
(
GWASs
)
have
identified
susceptibility
loci
in
a
number
of
cancers
and
such
studies
are
currently
underway
in
MM
.
To
date
,
GWASs
in
MM
have
identified
several
potential
regions
of
interest
for
further
study
on
chromosomes
3
p
22
,
7
p
15
.
3
,
8
q
24
and
2
p
23
.
3
.
In
addition
,
several
targets
of
paraproteins
(
so
called
'
paratargs
'
)
in
MM
have
been
identified
.
Hyperphosphorylation
of
the
paratarg
protein
,
which
is
inherited
in
an
autosomal
dominant
manner
,
appears
a
common
mechanism
underlying
the
antigenicity
of
these
proteins
.
One
particular
protein
,
hyperphosphorylated
paratarg-
7
(
pP-
7
)
is
a
common
target
in
persons
with
myeloma
and
has
also
been
identified
in
affected
members
of
several
high
-risk
MM
families
.
It
appears
that
the
frequency
of
pP-
7
as
an
antigenic
target
may
be
particularly
high
in
African
American
patients
with
MM
,
which
could
be
part
of
the
explanation
for
observed
racial
disparities
in
the
incidence
of
MM
.
In
this
review
we
focus
on
available
data
in
the
area
of
inherited
predisposition
to
MM
,
and
highlight
future
research
directions
.
Diseases
Validation
Diseases presenting
"common hematologic malignancy"
symptom
waldenström macroglobulinemia
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