Aromatase research and its clinical significance.

[aromatase deficiency]

Aromatase is a member of the cytochrome P 450 superfamily that catalyzes the conversion of androgens (C (19 )), namely testosterone and androstenedione , into oestrogens (C (18 )), oestradiol , and oestrone , respectively . The enzyme is active in various tissues in both females and males , thus oestrogens are produced not only in gonads but also in extra -gonadal localizations such as brain , adipose tissue , breast , skin , and bone . Aromatase gene CYP 19 A 1 located on chromosome 15 comprises nine coding exons and a number of alternative non-coding first exons that regulate tissue-specific expression . Studies on local regulation of aromatase expression and activity are important for understanding processes such as growth of oestrogen-dependent breast cancer . Rare clinical conditions of aromatase deficiency and excess have revealed some new and unexpected oestrogen functions in metabolism and bone health in both women and men . They were further studied using transgenic animal models such as aromatase knockout mice (ArKO ) or (AROM +) mice overexpressing human aromatase . Research on aromatase was important for its practical outcome as it contributed to the development of aromatase inhibitors (AIs ), an effective and safe group of drugs for the first -line endocrine therapy of breast cancer . Further studies are needed to establish AIs application in other oestrogen-dependent conditions , to overcome the resistance in breast cancer patients , and to develop tissue-specific selective inhibitors . (Pol J Endocrinol 2010 ; 61 (1 ): 126 -134 ).

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Diseases presenting "to overcome the resistance in breast cancer patients" symptom

aromatase deficiency

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