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[Follicular lymphoma complicated with myelofibrosis and macroglobulinemia at initial presentation].
[waldenström macroglobulinemia]
A
49
-
year
-old
woman
presented
with
pharyngeal
and
cervical
lymph
node
swelling
in
December
2010
.
Biopsy
of
the
pharynx
demonstrated
follicular
lymphoma
which
secreted
large
volumes
of
immunoglobulin
M
(
IgM
)
and
transforming
growth
factor
-β
(
TGF-β
)
.
Bone
marrow
aspiration
yielded
a
dry
tap
,
and
bone
marrow
biopsy
demonstrated
myelofibrosis
associated
with
lymphoma
cells
on
admission
.
The
plasma
concentration
of
TGF-β
was
elevated
and
monoclonal
IgM
gammopathy
was
detected
.
After
only
one
course
of
chemotherapy
with
CHOP
plus
rituximab
,
remission
of
both
lymphoma
and
myelofibrosis
was
achieved
.
Bone
marrow
aspiration
became
possible
,
and
TGF-β
and
IgM
levels
normalized
.
Thus
,
the
myelofibrosis
was
reversible
.
Diseases
Validation
Diseases presenting
"cervical lymph node"
symptom
waldenström macroglobulinemia
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