Rare Diseases Symptoms Automatic Extraction

Clinical significance of serum triple monoclonal components: a report of 6 cases and a review of the literature.

[waldenström macroglobulinemia]

A serum multiple monoclonal component (MC) is very rare. We here report 6 patients with 3 MCs. The triple MC was detected in all of them by immunofixation. 2/6 patients did not present hematological or oncological associated disease, while in the remaining 4, Waldenström macroglobulinaemia (2 cases), Polycythemia Vera and non-Hodgkin lymphoma were diagnosed. Of the 49 global patients reported in the literature (6+43), 64.6% had a lymphoproliferative disorder and only in 3 cases there was no associated disease. Therefore, the detection of such laboratory evidence should propel physicians to a deeper investigation.

Diseases presenting "hodgkin lymphoma" symptom

  • esophageal adenocarcinoma
  • hodgkin lymphoma, classical
  • monosomy 21
  • primary effusion lymphoma
  • severe combined immunodeficiency
  • systemic capillary leak syndrome
  • waldenström macroglobulinemia

This symptom has already been validated