Rare Diseases Symptoms Automatic Extraction
Home
A random Abstract
Our Project
Our Team
Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.
[waldenström macroglobulinemia]
Activation
of
the
Janus
kinase
family
/
signal
transducer
and
activator
of
transcription
(
JAK
/
STAT
)
signaling
pathway
has
been
associated
with
the
pathogenesis
and
progression
of
both
solid
and
hematologic
malignancies
.
We
have
detected
constitutive
activation
of
STAT
5
in
malignant
B
cells
derived
from
patients
with
Waldenström
's
macroglobulinemia
(
WM
)
.
Although
short
hairpin
RNA-mediated
knockdown
of
the
STAT
5
A
and
STAT
5
B
isoforms
did
not
affect
cellular
proliferation
,
loss
of
STAT
5
significantly
decreased
immunoglobulin
M
(
IgM
)
secretion
.
A
similar
dose-dependent
inhibition
of
IgM
secretion
was
observed
when
WM
cell
lines
were
treated
with
a
small
molecule
inhibitor
of
STAT
5
.
These
data
suggest
that
STAT
5
is
involved
in
regulating
IgM
production
in
WM
and
that
inhibition
of
STAT
5
may
represent
a
novel
therapeutic
strategy
for
lowering
IgM
levels
in
WM
patients
.
Diseases
Validation
Diseases presenting
"small molecule inhibitor"
symptom
dedifferentiated liposarcoma
systemic capillary leak syndrome
waldenström macroglobulinemia
You can validate or delete this automatically detected symptom
Validate the Symptom
Delete the Symptom
