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MYD88 and beyond: novel opportunities for diagnosis, prognosis and treatment in Waldenström's Macroglobulinemia.
[waldenström macroglobulinemia]
Waldenström
's
Macroglobulinemia
(
WM
)
is
a
rare
disease
of
the
elderly
with
a
median
age
of
63
-
68
years
at
diagnosis
.
Despite
recent
progress
in
biological
insights
and
therapeutics
,
WM
remains
clinically
challenging
to
diagnose
and
is
difficult
to
manage
with
significant
morbidity
and
lack
of
established
curative
therapies
.
Recently
,
the
use
of
whole-genome
sequencing
has
helped
to
identify
a
highly
recurrent
somatic
mutation
,
myeloid
differentiation
factor
88
[
MYD
88
]
L
265
P
in
WM
.
This
has
fueled
major
interest
in
the
field
and
as
newer
evidence
accumulates
,
it
is
clear
that
that
discovery
of
MYD
88
L
265
P
mutation
may
represent
an
important
breakthrough
in
understanding
the
pathogenesis
of
WM
and
lymphoproliferative
disorders
.
Recent
scientific
work
in
this
field
has
also
guided
the
identification
of
new
targets
such
as
CXCR
4
and
PI
3
K
-
delta
that
may
have
major
implications
in
the
future
treatment
of
WM
.
This
review
discusses
the
role
of
MYD
88
L
265
P
mutations
as
well
as
targets
beyond
MYD
88
in
the
setting
of
pathogenesis
and
development
of
future
rational
therapeutic
trials
focusing
on
patients
diagnosed
with
WM
.
Diseases
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waldenström macroglobulinemia
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