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Elevated risk of venous but not arterial thrombosis in Waldenström macroglobulinemia/lymphoplasmacytic lymphoma.
[waldenström macroglobulinemia]
Many
malignancies
,
including
multiple
myeloma
and
its
precursor
,
monoclonal
gammopathy
of
unknown
significant
,
are
associated
with
an
elevated
risk
of
thromboembolism
.
There
is
limited
information
on
the
risk
of
thrombosis
in
patients
with
Waldenström
macroglobulinemia
(
WM
)
and
lymphoplasmacytic
lymphoma
(
LPL
)
.
To
assess
the
risk
of
venous
and
arterial
thrombosis
in
WM
/
LPL
patients
in
a
large
population-based
cohort
study
in
Sweden
.
A
total
of
2190
patients
with
WM
/
LPL
and
8086
matched
controls
were
identified
through
Swedish
registers
between
1987
and
2005
.
Information
on
occurrence
of
venous
and
arterial
thrombosis
after
the
diagnosis
of
WM
/
LPL
was
obtained
through
the
centralized
Swedish
Patient
Register
,
with
follow-up
to
2006
.
Cox
regression
models
were
used
to
calculate
hazard
ratios
(
HRs
)
and
95
%
confidence
intervals
(
CIs
)
.
Patients
with
WM
/
LPL
had
a
significantly
increased
risk
of
venous
thrombosis
and
the
highest
risk
was
observed
during
the
first
year
following
diagnosis
(
HR
Â
=
Â
4
.
0
,
95
%
CI
2
.
5
-
6
.
4
)
.
The
risk
was
significantly
elevated
5
(
HR
Â
=
Â
2
.
3
,
95
%
CI
1
.
7
-
3
.
0
)
and
10
Â
years
after
diagnosis
(
HR
Â
=
Â
2
.
0
,
95
%
CI
1
.
6
-
2
.
5
)
.
There
was
no
increased
risk
of
arterial
thrombosis
during
any
period
of
follow-up
time
(
10
-
year
HR
Â
=
Â
1
.
0
,
95
%
CI
0
.
9
-
1
.
1
)
.
Venous
thrombosis
is
a
significant
cause
of
morbidity
in
patients
with
WM
/
LPL
.
The
potential
role
of
thromboprophylaxis
in
WM
/
LPL
,
especially
during
the
first
year
after
diagnosis
and
in
patients
treated
with
thrombogenic
agents
,
needs
to
be
assessed
to
further
improve
outcome
in
WM
/
LPL
patients
.
Diseases
Validation
Diseases presenting
"multiple myeloma"
symptom
erdheim-chester disease
esophageal adenocarcinoma
familial mediterranean fever
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
wolf-hirschhorn syndrome
This symptom has already been validated
