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Waldenström macroglobulinemia in hepatitis C: case report and review of the current literature.
[waldenström macroglobulinemia]
Background
.
Recent
literature
has
associated
hepatitis
C
virus
with
the
development
of
non-
Hodgkin
lymphoma
.
Hepatitis
C
virus
infection
appears
to
promote
lymphoproliferation
,
providing
a
plausible
mechanism
for
a
causative
association
;
however
,
despite
prior
reports
of
patients
with
comorbid
hepatitis
C
infection
and
Waldenström
macroglobulinemia
,
the
literature
is
in
disagreement
regarding
whether
there
exists
an
association
between
these
two
conditions
.
Case
Presentation
.
This
case
report
describes
a
57
-
year
-old
African-
American
male
with
chronic
hepatitis
C
infection
and
cryoglobulinemia
who
presented
with
several
episodes
of
transient
confusion
and
paralysis
and
was
found
to
have
symptomatic
hyperviscosity
.
The
recognition
of
his
condition
was
facilitated
by
characteristic
findings
on
ophthalmologic
examination
.
He
was
subsequently
diagnosed
with
Waldenström
macroglobulinemia
on
bone
marrow
biopsy
.
Conclusions
.
An
up
to
date
,
comprehensive
review
of
the
literature
suggests
an
association
between
hepatitis
C
and
Waldenström
macroglobulinemia
.
Data
on
optimal
treatment
of
patients
with
comorbid
hepatitis
C
infection
and
Waldenström
macroglobulinemia
is
limited
.
We
have
provided
a
comprehensive
review
of
previously
explored
treatment
options
to
guide
management
of
other
similar
patients
.
Our
patient
has
since
been
treated
with
repeated
plasmapheresis
with
a
plan
to
pursue
antiviral
therapy
.
Diseases
Validation
Diseases presenting
"hodgkin lymphoma"
symptom
esophageal adenocarcinoma
hodgkin lymphoma, classical
monosomy 21
primary effusion lymphoma
severe combined immunodeficiency
systemic capillary leak syndrome
waldenström macroglobulinemia
This symptom has already been validated
